HORDB

ID: hor006384
Uniprot ID: P06303
Protein name: C-terminal peptide
Gene name: Ppy
Organism: Rattus norvegicus (Rat)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031841 neuropeptide Y receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007631 feeding behavior; GO:0008150 biological_process
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm

Sequence: DEDTAGLPGRQLPPCTSLLVGLMPCAAARS
Length: 30
Propeptide: MAVAYYCLSLFLLSTWVALLLQPLQGAWGAPLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRYGKRDEDTAGLPGRQLPPCTSLLVGLMPCAAARS
Signal peptide: MAVAYYCLSLFLLSTWVALLLQPLQGAWG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006384_AF2.pdb

hor006384_ESM.pdb

Mass:	355799	Formula:	C128H215N37O42S3
Absent amino acids:	FHIKNWY	Common amino acids:	L
pI:	4.37	Basic residues:	2
Polar residues:	9	Hydrophobic residues:	10
Hydrophobicity:	12.33	Boman Index:	-2796
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	88
Instability Index:	6906	Extinction Coefficient cystines:	125
Absorbance 280nm:	4.31

PubMed ID: 3009446
Title: Mosaic evolution of prepropancreatic polypeptide.
PubMed ID: 3343236
Title: Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene.
PubMed ID: 3214179
Title: Different splice site utilization generates diversity between the rat and human pancreatic polypeptide precursors.