General Information

  • ID:  hor006384
  • Uniprot ID:  P06303
  • Protein name:  C-terminal peptide
  • Gene name:  Ppy
  • Organism:  Rattus norvegicus (Rat)
  • Family:  NPY family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031841 neuropeptide Y receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007631 feeding behavior; GO:0008150 biological_process
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm

Sequence Information

  • Sequence:  DEDTAGLPGRQLPPCTSLLVGLMPCAAARS
  • Length:  30(69-98)
  • Propeptide:  MAVAYYCLSLFLLSTWVALLLQPLQGAWGAPLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRYGKRDEDTAGLPGRQLPPCTSLLVGLMPCAAARS
  • Signal peptide:  MAVAYYCLSLFLLSTWVALLLQPLQGAWG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P06303-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006384_AF2.pdbhor006384_ESM.pdb

Physical Information

Mass: 355799 Formula: C128H215N37O42S3
Absent amino acids: FHIKNWY Common amino acids: L
pI: 4.37 Basic residues: 2
Polar residues: 9 Hydrophobic residues: 10
Hydrophobicity: 12.33 Boman Index: -2796
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 88
Instability Index: 6906 Extinction Coefficient cystines: 125
Absorbance 280nm: 4.31

Literature

  • PubMed ID:  3009446
  • Title:  Mosaic evolution of prepropancreatic polypeptide.
  • PubMed ID:  3343236
  • Title:  Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene.
  • PubMed ID:  3214179
  • Title:  Different splice site utilization generates diversity between the rat and huma